Disintegrins obtained from snake venom and their pharmacological potential | Zendy

Eric Abdel Eric Abdel Rivas-Mercado | Zendy; Lourdes GarzaOcañas | Zendy

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Disintegrins obtained from snake venom and their pharmacological potential

Author(s) -

Eric Abdel Eric Abdel Rivas-Mercado,

Lourdes GarzaOcañas

Publication year - 2017

Publication title -

medicina universitaria

Language(s) - English

Resource type - Journals

eISSN - 2530-0709

pISSN - 1665-5796

DOI - 10.1016/j.rmu.2017.02.004

Subject(s) - disintegrin , integrin , venom , microbiology and biotechnology , snake venom , angiogenesis , extracellular matrix , cell surface receptor , cell adhesion , cell , in vitro , biology , chemistry , metalloproteinase , biochemistry , cancer research , matrix metalloproteinase

Disintegrins are low molecular weight proteins (4–15 kDa) found in the venom of some snake species, these proteins act as integrin inhibitors. Integrins are membrane cell surface receptors formed by α–β subunits. These integrins modulate cell–cell and cell–extracellular matrix interactions. β 1 and β 3 integrins play important roles in angiogenesis and metastatic processes, suggesting that disintegrins may have utility in the development of new anticancer therapies. This review aims to show recent advances in disintegrin research and the evaluation of their biological activity in both in vitro and in vivo studies.

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