How I diagnose and treat lupus

Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disease of unknown origin with a waxing and waning course and a significant morbi-mortality. The objective of this paper is to provide an SLE overview, as well as recommendations regarding diagnosis and therapeutic concepts. In the first stage of the disease, the combination of genetic, gender and environmental factors culminate in the formation of autoantibodies years before the onset of symptoms is observed. In the second phase, there are clinical manifestations and associations with comorbidities. Management of patients with SLE should be predictive, preventive, personalized, and participatory in order to achieve remission and prevent relapses. We can divide SLE into three categories according to the severity of the disease: mild, moderate, and severe. Corticosteroids are the mainstay of therapy, but the use of another agent is mandatory in order to reduce side effects. Some of the biological agents