Open AccessA case of pulmonary tumor thrombotic microangiopathy associated with lung cancer diagnosed by cell-block immunohistochemistry of pulmonary microvascular cytology
Author(s) -
Hideaki Yamakawa,
Tomohiro Oba,
Hiroki Ohta,
Yuta Tsukahara,
Gen Kida,
Emiri Tsumiyama,
Tomotaka Nishizawa,
Rie Kawabe,
Shintaro Sato,
Keiichi Akasaka,
Masako Amano,
Kazuyoshi Kuwano,
Hidekazu Matsushima
Publication year - 2019
Publication title -
respiratory medicine case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.42
H-Index - 14
ISSN - 2213-0071
DOI - 10.1016/j.rmcr.2019.100956
Subject(s) - thrombotic microangiopathy , medicine , lung cancer , pathology , adenocarcinoma , lung , immunohistochemistry , biopsy , cancer , cytology , disease
Pulmonary tumor thrombotic microangiopathy (PTTM) is rare but should be considered as a possible diagnosis in patients with cancer. In this case, PTTM induced by lung cancer was more accurately diagnosed using cell block immunohistochemistry of pulmonary microvascular cytology (PMC) because we could confirm that lung adenocarcinoma was the origin of PTTM by the positive result of TTF-1 for atypical cells in PMC. The PMC procedure was minimally invasive and safer than lung biopsy. We believe that the cell block technique of PMC should be considered as one diagnostic option in PTTM.
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