The role of SCUBE1 in the development of late stent thrombosis presenting with ST-elevation myocardial infarction | Zendy

Hasan Ata Bolayır | Zendy; Tarık Kıvrak | Zendy; Hakan Güneş | Zendy; Dursun Akaslan | Zendy; Ömer Şahin | Zendy; Aslı Bolayır | Zendy

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The role of SCUBE1 in the development of late stent thrombosis presenting with ST-elevation myocardial infarction

Author(s) -

Hasan Ata Bolayır,

Tarık Kıvrak,

Hakan Güneş,

Dursun Akaslan,

Ömer Şahin,

Aslı Bolayır

Publication year - 2018

Publication title -

revista portuguesa de cardiologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.266

H-Index - 26

eISSN - 2174-2030

pISSN - 0870-2551

DOI - 10.1016/j.repc.2017.07.015

Subject(s) - medicine , cardiology , myocardial infarction , percutaneous coronary intervention , thrombosis , platelet activation , odds ratio , confidence interval , platelet

There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death. High platelet reactivity is a risk factor for thrombotic events, including late ST. For this reason, in the current study, we researched the role of SCUBE1 in the development of late coronary ST.

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