Open AccessIn vitro and in vivo studies on biodegradable magnesium alloy
Author(s) -
Lida Hou,
Zhen Li,
Yu Pan,
Lianteng Du,
Xinlin Li,
Yufeng Zheng,
Li Li
Publication year - 2014
Publication title -
progress in natural science materials international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 63
eISSN - 1745-5391
pISSN - 1002-0071
DOI - 10.1016/j.pnsc.2014.09.002
Subject(s) - biocompatibility , alloy , materials science , extrusion , magnesium alloy , microstructure , metallurgy , corrosion , in vivo , magnesium , biomedical engineering , medicine , microbiology and biotechnology , biology
The microstructure, mechanical property, electrochemical behavior and biocompatibility of magnesium alloy (BioDe MSM™) were studied in the present work. The experimental results demonstrated that grain refining induced by extrusion improves the alloy strength significantly from 162MPa for the as-cast alloy to 241MPa for the as-extruded one. The anticorrosion properties of the as-extruded alloy also increased. Furthermore, the hemolysis ratio was decreased from 4.7% for the as-cast alloy to 2.9% for the as-extruded one, both below 5%. BioDe MSM™ alloy shows good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the New Zealand rabbit, respectively, and there are no abnormalities after short-term implantation. In vivo observation indicated that the corrosion rate of this alloy varies with different implantation positions, with higher degradation rate in the femur than in the muscle
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