Open AccessMicroelectronics-embedded channel bridging and signal regeneration of injured spinal cords
Author(s) -
Zhigong Wang,
Xiaosong Gu,
Xiaoying Lü,
ZhengLin Jiang,
Wenyuan Li,
Guangming Lü,
Yufeng Wang,
Xiaoyan Shen,
Xintai Zhao,
Huiling Wang,
Zhenyu Zhang,
Hongmei Shen,
Wu Yang,
Weixing Shen,
Jingyang Zhang,
Dong Chen,
Xiaoyi Mao,
Shen Huaxiang
Publication year - 2009
Publication title -
progress in natural science materials international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 63
eISSN - 1745-5391
pISSN - 1002-0071
DOI - 10.1016/j.pnsc.2009.02.005
Subject(s) - microelectronics , spinal cord , sciatic nerve , neuroscience , signal (programming language) , biomedical engineering , regeneration (biology) , materials science , anatomy , medicine , computer science , biology , nanotechnology , microbiology and biotechnology , programming language
Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated.
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