Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models | Zendy

Fokko J. Huizing | Zendy; Bianca A.W. Hoeben | Zendy; Jasper Lok | Zendy; Otto C. Boerman | Zendy; Sandra Heskamp | Zendy; Johan Bussink | Zendy

Open Access

Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models

Author(s) -

Fokko J. Huizing,

Bianca A.W. Hoeben,

Jasper Lok,

Otto C. Boerman,

Sandra Heskamp,

Johan Bussink

Publication year - 2021

Publication title -

physics and imaging in radiation oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.777

H-Index - 12

ISSN - 2405-6316

DOI - 10.1016/j.phro.2021.08.004

Subject(s) - radioresistance , head and neck cancer , hypoxia (environmental) , head and neck , carbonic anhydrase , cancer , cancer research , radiation therapy , medicine , chemistry , biochemistry , enzyme , surgery , organic chemistry , oxygen

Tumor hypoxia is an important cause of radioresistance and is associated with poor outcome.SPECT (Single-photon emission computed tomography) imaging enables visualizing tumor characteristics. We investigated the SPECT-radiotracer [ 111 In]-girentuximab-F(ab') 2 to image Carbonic Anhydrase IX (CAIX), an enzyme upregulated under hypoxic conditions.

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