A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy | Zendy

Kristoffer Petersson | Zendy; Archonteia Kyroudi | Zendy; Jean Bourhis | Zendy; Crister Ceberg | Zendy; Tommy Knöös | Zendy; François Bochud | Zendy; Raphaël Moeckli | Zendy

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A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy

Author(s) -

Kristoffer Petersson,

Archonteia Kyroudi,

Jean Bourhis,

Crister Ceberg,

Tommy Knöös,

François Bochud,

Raphaël Moeckli

Publication year - 2017

Publication title -

physics and imaging in radiation oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.777

H-Index - 12

ISSN - 2405-6316

DOI - 10.1016/j.phro.2017.09.003

Subject(s) - measure (data warehouse) , plan (archaeology) , significant difference , quality (philosophy) , pareto optimal , pareto principle , radiation therapy , front (military) , medicine , multi objective optimization , medical physics , computer science , mathematics , statistics , mathematical optimization , data mining , biology , physics , paleontology , quantum mechanics , meteorology

We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference

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