Dengue infection in children with thalassemia - is it different? | Zendy

Vandana Bharadwaj | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Dengue infection in children with thalassemia - is it different?

Author(s) -

Vandana Bharadwaj

Publication year - 2018

Publication title -

pediatric hematology oncology journal

Language(s) - English

Resource type - Journals

ISSN - 2468-1245

DOI - 10.1016/j.phoj.2018.11.117

Subject(s) - medicine , dengue fever , interquartile range , thalassemia , pediatrics , anemia , vomiting , abdominal pain , hematocrit , immunology

Background: Children with thalassemia are at equal risk of getting dengue. Atypical manifestations of dengue in children with thalassemia are highlighted in studies from South Asia. Burden of suboptimal transfusion and chelation in children with thalassemia prompted us to undertake this study Objectives: To study the clinical course and short term outcome of children with thalassemia affected by dengue, and compare them to dengue infection in children without chronic illness. Methods: Retrospective case note review of children with thalassemia, admitted with dengue from April 2013 to April 2018. Comparison group included children without chronic disease admitted with dengue from November 2012 to April 2014. Severity, complications, hematological/ biochemical parameters, treatment given were analysed. Management was according to ‘WHO 2009 Guideline on Dengue’ Results: 15 children with Thalassemia (n=207) had confirmed dengue (NSI positive/ Dengue IgM positive), M: F=1:1.1, median age 6 years (interquartile range IQR 3-11). Median duration of hospital stay 6 (IQR 4-6) days. WHO Group A, B and C had 5, 6 and 4 patients respectively. Clinical features included fever in 15 (100%), persistent vomiting in 9 (60%), abdominal pain in 4 (26.7%) and excessive fluid accumulation in 2 (13.3%). 12 (80%) had anemia at presentation, median Hb 83 (IQR 70-101) g/l, while 2 (13.3%) had hematocrit >36%. 14 (93%) patients had platelets

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research