Metformin interferes with glucose cellular uptake by both estrogen and progesterone receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cell lines | Zendy

I Amaral | Zendy; C Silva | Zendy; Ana CorreiaBranco | Zendy; Fátima Martel | Zendy

Open Access

Metformin interferes with glucose cellular uptake by both estrogen and progesterone receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cell lines

Author(s) -

I Amaral,

C Silva,

Ana CorreiaBranco,

Fátima Martel

Publication year - 2017

Publication title -

porto biomedical journal

Language(s) - English

Resource type - Journals

eISSN - 2444-8672

pISSN - 2444-8664

DOI - 10.1016/j.pbj.2017.07.102

Subject(s) - metformin , endocrinology , mcf 7 , medicine , cell growth , breast cancer , cancer , growth inhibition , type 2 diabetes , glucose uptake , estrogen , diabetes mellitus , pharmacology , chemistry , insulin , human breast , biochemistry

s / Porto Biomed. J. 2017;2(5):176–246 219 Conclusion: These results suggest that cell viability loss promoted by 2-AG and AEA was associated with ER-stress since both PERK and IRE1 arms of UPR are activated. Prolonged ER-stress, contributes to the expression of pro-apoptotic proteins, such as CHOP. These findings shed light to the impact of endocannabinoids induced-ER stress which may negatively affect trophoblast cell turnover and pregnancy outcomes. Acknowledgements: This work received support from European Union (FEDER funds through COMPETE) and FCT through project PTDC/DTP-FTO/5651/2014-POCI-01-0145-FEDER016562; FCT/MEC through national funds and co-financed by FEDER, under PT2020 (UID/01/0145/FERDER/007728) and CCDRN/NORTE2020/Portugal 2020 (norte-01-0145-FEDER-000024).

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