Open AccessEffect of LPS on Allergic Eustachian Tube Dysfunction
Author(s) -
Campbell Adam,
Suberman Thomas,
Ebert Charles
Publication year - 2010
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1016/j.otohns.2010.06.589
Subject(s) - eustachian tube , medicine , audiology , immunology , middle ear , anatomy
Lipopolysaccharide (LPS) in the middle ear may play a role in the development of the allergic conditions that facilitate Eustachian tube dysfunction (ETD) and otitis media with effusion. This investigation seeks to utilize an established model of allergic ETD in rats to examine whether exposure to variable concentrations of LPS during antigen sensitization has an immunomodulatory effect.