Open AccessOtotoxicity After Oncologic Treatment to Head and Neck Tumors
Author(s) -
Lima Isaac Myriam,
DellAringa Ana Helena Bannwart,
Arruda Gustavo Viani,
DellAringa Alfredo Rafael
Publication year - 2010
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1016/j.otohns.2010.06.526
Subject(s) - ototoxicity , head and neck , medicine , head and neck cancer , oncology , surgery , radiation therapy , chemotherapy , cisplatin
Profa. Dra. Myriam L. Isaac Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo Brasil Email: mylis@fmrp.usp.br Objective: To evaluate the functionality of the auditory system in patients who underwent exclusive radiotherapy and chemoradiotherapy treatment with cisplatin to treat head and neck tumors. Study Design Case series with planned data collection. Setting: From May 2007 to May 2008 by the Department of Otorhinolaryngology and the Department of Oncology/Radiotherapy at Faculdade de Medicina de Marília. Subjects and Methods: Audiological evaluation (Pure Tone Audiometry (air and bone conduction), Speech Audiometry, Tympanometry, Acoustic Reflex testing and Distortion Product Otoacoustic Emissions) was performed in 49 patients diagnosed with head and neck neoplasia and treated with exclusive radiotherapy (19 patients) or chemoradiotherapy (30 patients). We considered as reduction of the auditory acuity, the decrease of 20 dB in an isolated frequency or of 10 dB in two or more successive frequencies, according to the American Speech-Language-Hearing Association (ASHA) criteria. Results: 10,5% left ears and 26,3% right ears presented decreased hearing soon after the radiotherapy treatment. 57 % left ears and 70% right ears presented decreased hearing soon after the chemoradiotherapy treatment All frequencies from 0.25KHz to 8kHz showed significant auditory damage (p < 0,05). Conclusions: Patients with head and neck cancer submitted to the conventional radiotherapy treatment, combined with the chemotherapy with cisplatin, presented a high incidence of decreased hearing by the end of treatment. Strong evidence was observed linking auditory alteration to the amount of radiotherapy treatment.. OTOTOXICITY AFTER ONCOLOGIC TREATMENT TO HEAD AND NECK TUMOR Myriam L. Isaac, PhD1; Ana Helena B. Dell ́Aringa, MD2; Gustavo V. Arruda, MD2; Alfredo R. Dell ́Aringa, PhD2 Departament of Otorhinolaryngology of FMUSPRP1 / Departament of Otorhinolaryngology of FAMEMA ́s General Hospital2