Open AccessInferior Turbinate: New Source of Mesenchymal Stromal Cells
Author(s) -
Kim Joohwan,
Kim Su Young
Publication year - 2010
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1016/j.otohns.2010.06.243
Subject(s) - stromal cell , mesenchymal stem cell , regeneration (biology) , tissue engineering , chondrogenesis , extracellular matrix , bone marrow , cartilage , clinical uses of mesenchymal stem cells , stem cell transplantation for articular cartilage repair , regenerative medicine , transplantation , pathology , stem cell , microbiology and biotechnology , cellular differentiation , biology , medicine , biomedical engineering , anatomy , adult stem cell , surgery , biochemistry , gene
Autologus transplantation of tissue or organ is useful method for reconstruction of damaged human structures. Because tissue sources for this replacement in human body are limited, engineered tissue is tested for the treatment option. However, cell sources of tissue engineering for the regeneration of human structure are limited also. Mesenchymal stromal cells have been a main focus to the field of tissue engineering and regeneration. Although the bone marrow stromal cells may be the best characterized of the stem cells, they are not easily obtained and are only a small percentage of the population of marrow. We sought to develop a method of cell culture that accelerates the production of cartilage, bone-specific extracellular matrix, and neuron by inducing the chondrogenic, osteogenic, and neurogenic differentiation of human turbinate mesenchy mal stromal cells (hTMSCs). Also, we aim to use this method as a original technique for tissue regeneration and functional restoration of organ and to develop the new cell source for mesenchymal stromal cells.