Open AccessS5– Generalizability of results from randomized trials
Author(s) -
Post Piet N.,
Guyatt Gordon H.
Publication year - 2010
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1016/j.otohns.2010.04.128
Subject(s) - generalizability theory , randomized controlled trial , psychology , medicine , developmental psychology
disease. RESULTS: We will present findings of reviews of published guidance and explore practical issues of applying these through comparing and contrasting the two approaches. Examples such as the utility of a set of diagnostic tools and the identification and use of appropriate surrogate measures will be presented. We will discuss how recommendations can be developed in the absence of a single valid reference standard and the acceptability of this concept in guideline development. DISCUSSION (CONCLUSION): Secondary researchers and guideline developers must embrace the use of innovative techniques when accepted methods of assessment and appraisal cannot be used; this is particularly relevant to the assessment of diagnostic studies as single valid and reliable reference standards may not be available. TARGET AUDIENCE(S): 1. Clinical researcher 2. Evidence synthesizer, developer of systematic reviews or meta-analyses 3. Guideline developer 4. Guideline implementer 5. Developer of guideline-based products 6. Health care policy analyst/policymaker 7. Allied health professionals 8. Consumers’ and patients’ representatives