Open AccessEffect of endoscopic sinus surgery on irradiation‐induced rhinosinusitis in patients with nasopharyngeal carcinoma
Author(s) -
Hu KoHsin,
Tan ChingTing,
Lin KaiNan,
Cheng YaJian,
Huang HungMeng
Publication year - 2008
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1016/j.otohns.2008.07.006
Subject(s) - medicine , saccharin , nasopharyngeal carcinoma , maxillary sinus , sinusitis , sinus (botany) , mucous membrane of nose , surgery , radical surgery , radiation therapy , pathology , cancer , biology , botany , genus
Objectives We evaluated the effect of endoscopic sinus surgery on irradiation‐induced rhinosinusitis of the maxillary‐sinus mucosa among patients with nasopharyngeal carcinoma (NPC). Design Surgical outcomes were evaluated by changes to the ultrastructure of the antral mucosa and nasomucociliary clearance. Methods Twenty‐one NPC patients with irradiation‐induced chronic sinusitis were enrolled in the study, along with five controls. Specimens were taken from 42 maxillary sinuses during surgery and 1 year after surgery. Saccharin transit time was measured before the initial surgery and 1 year after surgery. Results In the postoperative cases, we found a decrease in the number of the submucosal gland openings ( P < 0.05), the cilia in the antral mucosa regenerated ( P < 0.05), and the saccharin transit time reduced ( P < 0.05); the number of goblet cells did not change. Conclusion Endoscopic sinus surgery is an effective treatment for irradiation‐induced rhinosinusitis in NPC patients, improving ventilation and drainage of the paranasal sinuses, and facilitating regeneration of the sinus mucosa.