Open AccessCBX7 Inhibits Cell Growth and Motility and Induces Apoptosis in Cervical Cancer Cells
Author(s) -
Rong Li,
Qi Yan,
Ping Tian,
Yan Wang,
Jing Wang,
Tao Ning,
Ning Li,
Xin Lin,
Lu Ding,
Jiwen Liu,
Cailing Ma
Publication year - 2019
Publication title -
molecular therapy — oncolytics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.424
H-Index - 23
ISSN - 2372-7705
DOI - 10.1016/j.omto.2019.09.002
Subject(s) - downregulation and upregulation , cancer research , cervical cancer , cancer , apoptosis , cell , cell growth , cancer cell , cell culture , biology , motility , suppressor , medicine , microbiology and biotechnology , genetics , gene
The chromobox protein homolog 7 (CBX7), one member of the polycomb group family, has been characterized mainly to play a tumor-suppressive role in human malignant neoplasias. Moreover, downregulation of CBX7 is correlated with poor prognosis and aggressiveness in a variety of human cancers. However, the biological functions and role of CBX7 in cervical cancer have not been elucidated. In the present study, we explore whether CBX7 exerts its tumor-suppressive function in cervical cancer. To achieve this goal, molecular approaches were used to upregulate the expression of CBX7 or downregulation of CBX7 in cervical cancer cell lines. We observed that overexpression of CBX7 inhibited cell growth and induced apoptosis in cervical cancer cells. CBX7 overexpression retarded cell migration and invasion in cervical cancer cells. In line with this, downregulation of CBX7 promoted cell growth and migration as well as invasion in cervical cancer cells. Our findings suggest that CBX7 might be a tumor suppressor and could be a potential target in cervical cancer.
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