Open AccessCircular RNA in tumor metastasis
Author(s) -
Chao Zhang,
Rongfang Ding,
Yicheng Sun,
Si Tong Huo,
Alina T. He,
Chang Wen,
HongHao Chen,
William W. Du,
Weinan Lai,
Huijun Wang
Publication year - 2021
Publication title -
molecular therapy — nucleic acids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.208
H-Index - 59
ISSN - 2162-2531
DOI - 10.1016/j.omtn.2021.01.032
Subject(s) - circular rna , microrna , metastasis , biology , competing endogenous rna , carcinogenesis , translation (biology) , rna , gene , epithelial–mesenchymal transition , cancer research , autophagy , computational biology , tumor progression , gene expression , cancer , long non coding rna , genetics , messenger rna , apoptosis
Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed.
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