Aptamers for CD Antigens: From Cell Profiling to Activity Modulation | Zendy

Amin Nozari | Zendy; Maxim V. Berezovski | Zendy

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Aptamers for CD Antigens: From Cell Profiling to Activity Modulation

Author(s) -

Amin Nozari,

Maxim V. Berezovski

Publication year - 2016

Publication title -

molecular therapy — nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.208

H-Index - 59

ISSN - 2162-2531

DOI - 10.1016/j.omtn.2016.12.002

Subject(s) - aptamer , profiling (computer programming) , computational biology , antigen , chemistry , microbiology and biotechnology , biology , immunology , computer science , operating system

Nucleic acid-based aptamers are considered to be a promising alternative to antibodies because of their strong and specific binding to diverse targets, fast and inexpensive chemical synthesis, and easy labeling with a fluorescent dye or therapeutic agent. Cluster of differentiation (CD) proteins are among the most popular antigens for aptamers on the cell surface. These anti-CD aptamers could be used in cell biology and biomedicine, from simple cell phenotyping by flow cytometry or fluorescent microscopy to diagnosis and treatment of HIV/AIDS to cancer and immune therapies. The unique feature of aptamers is that they can act simultaneously as an agonist and antagonist of CD receptors depending on a degree of aptamer oligomerization. Aptamers can also deliver small interfering RNA to silence vital genes in CD-positive cells. In this review, we summarize nucleic acid sequences of anti-CD aptamers and their use, which have been validated in multiple studies.

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