Characteristics of the Coronavirus Disease 2019 and related Therapeutic Options | Zendy

Boxuan Huang | Zendy; Rongsong Ling | Zendy; Yifan Cheng | Zendy; Jieqi Wen | Zendy; Yarong Dai | Zendy; Wenjie Huang | Zendy; Siyan Zhang | Zendy; Xifeng Lu | Zendy; Yifeng Luo | Zendy; Yi-Zhou Jiang | Zendy

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Characteristics of the Coronavirus Disease 2019 and related Therapeutic Options

Author(s) -

Boxuan Huang,

Rongsong Ling,

Yifan Cheng,

Jieqi Wen,

Yarong Dai,

Wenjie Huang,

Siyan Zhang,

Xifeng Lu,

Yifeng Luo,

Yi-Zhou Jiang

Publication year - 2020

Publication title -

molecular therapy — methods and clinical development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.285

H-Index - 32

ISSN - 2329-0501

DOI - 10.1016/j.omtm.2020.06.013

Subject(s) - covid-19 , coronavirus , disease , virology , pandemic , medicine , infectious disease (medical specialty) , outbreak

The coronavirus disease 2019 (COVID-19) is a new type of pneumonia caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. COVID-19 is affecting millions of patients, and the infected number keeps increasing. SARS-CoV-2 is highly infectious, has a long incubation period, and causes a relatively high death rate, resulting in severe health problems all over the world. Currently there is no effective proven drug for the treatment of COVID-19; therefore, development of effective therapeutic drugs to suppress SARS-CoV-2 infection is urgently needed. In this review, we first summarize the structure and genome features of SARS-CoV-2 and introduce its infection and replication process. Then, we review the clinical symptoms, diagnosis, and treatment options of COVID-19 patients. We further discuss the potential molecular targets and drug development strategies for treatment of the emerging COVID-19. Finally, we summarize clinical trials of some potential therapeutic drugs and the results of vaccine development. This review provides some insights for the treatment of COVID-19.

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