Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons | Zendy

Luke K. Burke | Zendy; Barbora Doslikova | Zendy; Giuseppe D’Agostino | Zendy; Megan Greenwald-Yarnell | Zendy; Teodora Georgescu | Zendy; Raffaella Chianese | Zendy; Pablo B. Martínez de Morentin | Zendy; Emmanuel Ogunnowo-Bada | Zendy; Céline Cansell | Zendy; Lourdes Valencia-Torres | Zendy; Alastair S. Garfield | Zendy; John ApergisSchoute | Zendy; Daniel D. Lam | Zendy; John R. Speakman | Zendy; Marcelo Rubinstein | Zendy; Malcolm J. Low | Zendy; Justin J. Rochford | Zendy; Martin G. Myers | Zendy; Mark L. Evans | Zendy; Lora K. Heisler | Zendy

Open Access

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Author(s) -

Luke K. Burke,

Barbora Doslikova,

Giuseppe D’Agostino,

Megan Greenwald-Yarnell,

Teodora Georgescu,

Raffaella Chianese,

Pablo B. Martínez de Morentin,

Emmanuel Ogunnowo-Bada,

Céline Cansell,

Lourdes Valencia-Torres,

Alastair S. Garfield,

John ApergisSchoute,

Daniel D. Lam,

John R. Speakman,

Marcelo Rubinstein,

Malcolm J. Low,

Justin J. Rochford,

Martin G. Myers,

Mark L. Evans,

Lora K. Heisler

Publication year - 2016

Publication title -

molecular metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.848

H-Index - 65

ISSN - 2212-8778

DOI - 10.1016/j.molmet.2016.01.005

Subject(s) - endocrinology , hypothalamus , medicine , energy homeostasis , agonist , appetite , biology , adipose tissue , receptor , melanocortin , homeostasis , obesity

Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-opiomelanocortin (POMC) peptides, perturbations of which disrupt energy balance and promote severe obesity. However, POMC neurons are neurochemically diverse and the crucial source of POMC peptides that regulate energy homeostasis and body weight remains to be fully clarified.

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