Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance | Zendy

Mar Quiñones | Zendy; Omar Al–Massadi | Zendy; Rosalı́a Gallego | Zendy; Johan Fernø | Zendy; Carlos Diéguez | Zendy; Miguel López | Zendy; Rubén Nogueiras | Zendy

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Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance

Author(s) -

Mar Quiñones,

Omar Al–Massadi,

Rosalı́a Gallego,

Johan Fernø,

Carlos Diéguez,

Miguel López,

Rubén Nogueiras

Publication year - 2015

Publication title -

molecular metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.848

H-Index - 65

ISSN - 2212-8778

DOI - 10.1016/j.molmet.2015.09.014

Subject(s) - glucagon , medicine , endocrinology , ampk , glucagon receptor , protein kinase a , arc (geometry) , chemistry , biology , kinase , insulin , biochemistry , geometry , mathematics

Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes. Among its variety of actions, glucagon reduces food intake, but the molecular mechanisms mediating this effect as well as glucagon resistance are totally unknown.

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