Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury | Zendy

Johanna L. Hannan | Zendy; Maarten Albersen | Zendy; Ömer Kutlu | Zendy; Christian Gratzke | Zendy; Christian G. Stief | Zendy; Arthur L. Burnett | Zendy; Jeffrey J. Lysiak | Zendy; Petter Hedlund | Zendy; Trinity J. Bivalacqua | Zendy

Open Access

Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

Author(s) -

Johanna L. Hannan,

Maarten Albersen,

Ömer Kutlu,

Christian Gratzke,

Christian G. Stief,

Arthur L. Burnett,

Jeffrey J. Lysiak,

Petter Hedlund,

Trinity J. Bivalacqua

Publication year - 2012

Publication title -

the journal of urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.402

H-Index - 256

eISSN - 1527-3792

pISSN - 0022-5347

DOI - 10.1016/j.juro.2012.09.104

Subject(s) - medicine , erectile function , nitric oxide , apoptosis , erectile dysfunction , nerve injury , penis , pharmacology , endocrinology , anesthesia , anatomy , biochemistry , chemistry

Bilateral cavernous nerve injury results in up-regulation of ROCK signaling in the penis. This is linked to erectile dysfunction in an animal model of post-prostatectomy erectile dysfunction. We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury.

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