Mesenchymal stem cell secretions improve donor heart function following ex vivo cold storage | Zendy

Meijing Wang | Zendy; Liangliang Yan | Zendy; Qianzhen Li | Zendy; Yang Yang | Zendy; Mark W. Turrentine | Zendy; Keith L. March | Zendy; IWen Wang | Zendy

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Mesenchymal stem cell secretions improve donor heart function following ex vivo cold storage

Author(s) -

Meijing Wang,

Liangliang Yan,

Qianzhen Li,

Yang Yang,

Mark W. Turrentine,

Keith L. March,

IWen Wang

Publication year - 2020

Publication title -

journal of thoracic and cardiovascular surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.458

H-Index - 192

eISSN - 1085-8687

pISSN - 0022-5223

DOI - 10.1016/j.jtcvs.2020.08.095

Subject(s) - mesenchymal stem cell , exosome , ex vivo , cold storage , cardioprotection , medicine , transplantation , microvesicles , reperfusion injury , ischemia , paracrine signalling , pharmacology , in vivo , chemistry , pathology , biology , microrna , receptor , biochemistry , microbiology and biotechnology , horticulture , gene

Heart transplantation is the gold standard of treatments for end-stage heart failure, but its use is limited by extreme shortage of donor organs. The time "window" between procurement and transplantation sets the stage for myocardial ischemia/reperfusion injury, which constrains the maximal storage time and lowers use of donor organs. Given mesenchymal stem cell (MSC)-derived paracrine protection, we aimed to evaluate the efficacy of MSC-conditioned medium (CM) and extracellular vesicles (EVs) when added to ex vivo preservation solution on ameliorating ischemia/reperfusion-induced myocardial damage in donor hearts.

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