Chronic Tumor Necrosis Factor-α Infusion in Gravid C57BL6/J Mice Accelerates Adipose Tissue Development in Female Offspring | Zendy

Suzan Lambin | Zendy; Rita van Bree | Zendy; Ignace Vergote | Zendy; Johan Verhaeghe | Zendy

Open Access

Chronic Tumor Necrosis Factor-α Infusion in Gravid C57BL6/J Mice Accelerates Adipose Tissue Development in Female Offspring

Author(s) -

Suzan Lambin,

Rita van Bree,

Ignace Vergote,

Johan Verhaeghe

Publication year - 2006

Publication title -

journal of the society for gynecologic investigation

Language(s) - English

Resource type - Journals

eISSN - 1556-7117

pISSN - 1071-5576

DOI - 10.1016/j.jsgi.2006.09.001

Subject(s) - offspring , endocrinology , medicine , adipose tissue , leptin , adipokine , tumor necrosis factor alpha , insulin resistance , adipocyte , white adipose tissue , weaning , pregnancy , gestation , insulin , biology , obesity , genetics

Tumor necrosis factor (TNF)-alpha is thought to mediate, in part, the link between obesity and insulin resistance, and women with gestational diabetes mellitus (GDM) have raised serum TNF-alpha concentrations. Our objective was to investigate whether systemic TNF-alpha administration into gravid C57BL6/J mice causes a GDM-like syndrome and affects growth and adipose tissue (AT) development in the offspring.

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