Open AccessEvaluation of nuclear unrest and p53 immunostaining in Wilms’ tumor
Author(s) -
Asmaa Salama,
Ahmad Kamel
Publication year - 2011
Publication title -
journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2011.07.005
Subject(s) - anaplasia , wilms' tumor , immunostaining , blastema , immunohistochemistry , medicine , stage (stratigraphy) , pathology , biology , regeneration (biology) , paleontology , microbiology and biotechnology
Nuclear unrest is a term applied to Wilms' tumors (WT) that show nuclear abnormalities close to anaplasia but without abnormal mitoses. p53 is claimed to be associated with anaplasia and poor prognosis. This study was undertaken to evaluate the clinical significance of nuclear unrest and p53 immunostaining in Wilms' tumor.
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