Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis | Zendy

Antonio Riva | Zendy; Elizabeth Gray | Zendy; Sarah Azarian | Zendy; Ane Zamalloa | Zendy; Mark McPhail | Zendy; Royce P Vincent | Zendy; Roger Williams | Zendy; Shilpa Chokshi | Zendy; Vishal Patel | Zendy; Lindsey Edwards | Zendy

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Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis

Author(s) -

Antonio Riva,

Elizabeth Gray,

Sarah Azarian,

Ane Zamalloa,

Mark McPhail,

Royce P Vincent,

Roger Williams,

Shilpa Chokshi,

Vishal Patel,

Lindsey Edwards

Publication year - 2020

Publication title -

jhep reports

Language(s) - English

Resource type - Journals

ISSN - 2589-5559

DOI - 10.1016/j.jhepr.2020.100151

Subject(s) - cirrhosis , immunology , inflammation , medicine , cytokine , calprotectin , inflammatory bowel disease , disease

FC-profiling represents an innovative approach to investigating the localised intestinal cytokine microenvironment in cirrhosis. These data reveal that AD is associated with a highly inflamed and permeable gut-barrier. FC profiles are very different from the classical innate-like features of systemic inflammation. There is non-specific upregulation of T1/T17 effector cytokines and those known to mediate intestinal barrier damage. This prevents mucosal healing in AD and further propagates BT and systemic inflammation.

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