Open AccessMethylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis
Author(s) -
Michael Trauner,
Yevgeniy Gindin,
Zhaoshi Jiang,
Chuhan Chung,
G. Mani Subramanian,
Robert P. Myers,
Aliya Gulamhusein,
Kris V. Kowdley,
Cynthia Levy,
Zachary Goodman,
Michael P. Manns,
Andrew J. Muir,
Christopher L. Bowlus
Publication year - 2019
Publication title -
jhep reports
Language(s) - English
Resource type - Journals
ISSN - 2589-5559
DOI - 10.1016/j.jhepr.2019.11.004
Subject(s) - primary sclerosing cholangitis , medicine , gastroenterology , cohort , hazard ratio , cirrhosis , liver biopsy , confidence interval , biopsy , disease
An epigenetic clock based on DNA methylation has been proposed as a marker of age. In liver diseases such as non-alcoholic steatohepatitis, age acceleration based on this epigenetic clock has been observed. Herein, we show that patients with primary sclerosing cholangitis have marked age acceleration, which is further accentuated by worsening fibrosis. This measure of age acceleration could be a useful marker for prognostication or risk stratification in primary sclerosing cholangitis.
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