Intracranial Toxoplasma gondii granuloma in a cat

An 8-year-old cat with recent-onset generalized seizures was diagnosed with aright forebrain mass using magnetic resonance imaging. The mass was excised andupon histologic and immunohistochemical examination shown to be aToxoplasma gondii granuloma. Serology supported activeT gondii infection. The cat was treated with phenobarbitalto control seizures. After definitive diagnosis of toxoplasma granuloma,clindamycin was administered for approximately 1 month. Seizures recurred 8months after initial presentation, and the cat was euthanased at the owner'srequest. This is a previously unreported manifestation of feline central nervoussystem toxoplasmosis. When a mass lesion is present in the brain of a cat andserologic test results support active infection with T gondii ,toxoplasma granuloma must be a differential diagnosis. If the patient issuffering from clinical disease, surgical resection of the mass (if possible)can be complimented with medical treatment until definitive diagnosis isobtained. Immunocompromising factors should be identified and addressed ifpossible.