Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression | Zendy

RuYin Tsai | Zendy; Juei-Chii Wang | Zendy; Kuang-Yi Chou | Zendy; ChihShung Wong | Zendy; ChenHwan Cherng | Zendy

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Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

Author(s) -

RuYin Tsai,

Juei-Chii Wang,

Kuang-Yi Chou,

ChihShung Wong,

ChenHwan Cherng

Publication year - 2015

Publication title -

journal of the formosan medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.708

H-Index - 54

eISSN - 1876-0821

pISSN - 0929-6646

DOI - 10.1016/j.jfma.2015.05.010

Subject(s) - morphine , medicine , resveratrol , pharmacology , neuroinflammation , nociception , hdac1 , anesthesia , neuropathic pain , inflammation , receptor , histone deacetylase , chemistry , biochemistry , gene , histone

We previously showed that subsequent intrathecal (i.t.) injection of resveratrol (30 μg) significantly reverses morphine-evoked neuroinflammation in morphine-tolerant rats. The present study examined the underlying mechanism.

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