Use of photodynamic therapy and acitretin in generalized eruptive keratoacanthoma of Grzybowski

Generalized eruptive keratoacanthoma of Grzybowski (GEKG), a rare variant of keratoacanthoma (KA),1 affects widespread areas of the skin and mucous membranes. First described in 1950,2 this condition is exceptionally difficult to treat. Systemic retinoids or cyclophosphamide, although sometimes effective, may not be well tolerated. We report a case of severe GEKG, unresponsive to multiple systemic agents, in which photodynamic therapy was used successfully along with acitretin for disease management.