Analysis of neutrophil–lymphocyte ratio as a prognostic element in the response to neoadjuvant therapy in rectal cancer | Zendy

Leonardo Vieira Polli | Zendy; Mauro Pinho | Zendy

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Analysis of neutrophil–lymphocyte ratio as a prognostic element in the response to neoadjuvant therapy in rectal cancer

Author(s) -

Leonardo Vieira Polli,

Mauro Pinho

Publication year - 2015

Publication title -

journal of coloproctology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.167

H-Index - 11

eISSN - 2317-6423

pISSN - 2237-9363

DOI - 10.1016/j.jcol.2015.01.003

Subject(s) - medicine , colorectal cancer , chemotherapy , radiation therapy , complete response , neutrophil to lymphocyte ratio , neoadjuvant therapy , lymphocyte , peripheral blood , oncology , gastroenterology , peripheral , cancer , breast cancer

The previous radio-chemotherapy approach is highly relevant in the management of rectal cancer, collaborating on organ functional preservation, being performed prior to surgery. The inflammatory response plays an important role in this treatment.ObjectiveIt consists in correlating the number of peripheral lymphocytes and the neutrophil/lymphocyte ratio in the peripheral blood with tumor response to neoadjuvant therapy.MethodsReview of medical records of patients with rectal cancer in HMSJ and HSJ Oncology Services since 2009 – cases submitted to neoadjuvant treatment with radio-chemotherapy.ResultsOf those 96 patients with this disease who underwent neoadjuvant therapy with radio-chemotherapy, 35 patients were eligible; complete tumor response was observed in 11 cases (31%), and 9 were submitted to surgical treatment. Comparing the leukocyte parameters between patients with complete response (CR) and incomplete response (IR) the following values were observed: total number of leukocytes (mean) CR 7390.9×IR 7220.4 (p=0.8); total lymphocytes CR 2103×IR 1960.9 (p=0.4); neutrophil/lymphocyte ratio CR 3.55×IR 3.79 (p=0.5). The mean radiotherapy dose was 49.1Gy, with CR 47.3×IR 50.0 (p=0.06).ConclusionIt was not possible to demonstrate in this study a significant relationship between complete tumor response to neoadjuvant therapy with respect to blood leukocyte parameters analyzed

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