Open AccessCancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance
Author(s) -
Jiaye Liu,
Pengfei Li,
Ling Wang,
Meng Li,
Zhouhong Ge,
Lisanne Noordam,
Ruby Lieshout,
Monique M.A. Verstegen,
Buyun Ma,
Junhong Su,
Qin Yang,
Ruyi Zhang,
Guoying Zhou,
Lucia Campos Carrascosa,
Dave Sprengers,
Jan N.M. IJzermans,
Ron Smits,
Jaap Kwekkeboom,
Luc J. W. van der Laan,
Maikel P. Peppelenbosch,
Qiuwei Pan,
Wanlu Cao
Publication year - 2020
Publication title -
cellular and molecular gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.417
H-Index - 38
ISSN - 2352-345X
DOI - 10.1016/j.jcmgh.2020.09.003
Subject(s) - organoid , stromal cell , cancer associated fibroblasts , cancer , cancer research , medicine , niche , biology , oncology , cancer cell , microbiology and biotechnology , ecology
Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell-CAF interactions. Here, we aimed to establish 3-dimensional (3D) organotypic co-cultures of primary liver tumor-derived organoids with CAFs, and to understand their interactions and the response to treatment.
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