Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis | Zendy

Rosa MartínMateos | Zendy; Thiago M. de Assuncao | Zendy; Juan Pablo Arab | Zendy; Nidhi JalanSakrikar | Zendy; Usman Yaqoob | Zendy; Thomas Greuter | Zendy; Vikas Verma | Zendy; Angela Mathison | Zendy; Sheng Cao | Zendy; Gwen Lomberk | Zendy; Philippe Mathurin | Zendy; Raúl Urrutia | Zendy; Robert C. Huebert | Zendy; Vijay H. Shah | Zendy

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Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Author(s) -

Rosa MartínMateos,

Thiago M. de Assuncao,

Juan Pablo Arab,

Nidhi JalanSakrikar,

Usman Yaqoob,

Thomas Greuter,

Vikas Verma,

Angela Mathison,

Sheng Cao,

Gwen Lomberk,

Philippe Mathurin,

Raúl Urrutia,

Robert C. Huebert,

Vijay H. Shah

Publication year - 2018

Publication title -

cellular and molecular gastroenterology and hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.417

H-Index - 38

ISSN - 2352-345X

DOI - 10.1016/j.jcmgh.2018.09.005

Subject(s) - hepatic stellate cell , liver fibrosis , cancer research , ezh2 , transforming growth factor , fibrosis , hepatic fibrosis , chemistry , microbiology and biotechnology , medicine , biology , biochemistry , epigenetics , gene

Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators after liver injury. The aim of this study was to analyze the epigenetic modulators that differentially control TGF-β and PDGF signaling pathways.

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