Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis by regulating the expression of endothelin-1 and calcitonin gene-related peptide in rats | Zendy

Xiang-Qun Zhang | Zendy; Jian-Gong Hu | Zendy; Yuzhen Zhuo | Zendy; Lihua Cui | Zendy; Caixia Li | Zendy; Naiqiang Cui | Zendy; Shukun Zhang | Zendy

Open Access

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis by regulating the expression of endothelin-1 and calcitonin gene-related peptide in rats

Author(s) -

Xiang-Qun Zhang,

Jian-Gong Hu,

Yuzhen Zhuo,

Lihua Cui,

Caixia Li,

Naiqiang Cui,

Shukun Zhang

Publication year - 2017

Publication title -

journal of the chinese medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 42

eISSN - 1728-7731

pISSN - 1726-4901

DOI - 10.1016/j.jcma.2017.09.005

Subject(s) - amygdalin , medicine , calcitonin gene related peptide , endocrinology , fibrosis , transforming growth factor , glial cell line derived neurotrophic factor , endothelin 1 , pathology , neuropeptide , neurotrophic factors , receptor , alternative medicine

The pathogenesis of chronic pancreatitis (CP) is a complex process of interaction between tissue injury and repair, which involves microcirculatory disturbance. Amygdalin, an effective component extracted from Semen Persicae (a kind of Chinese herbal medicine), can decrease blood viscosity and improve microcirculation. In this study, we investigated the therapeutic effects of amygdalin on pancreatic fibrosis in rats with CP.

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