Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China | Zendy

Juan Ni | Zendy; Ling Zhang | Zendy; Tao Zhou | Zendy; Weijiang Xu | Zendy; Jinglun Xue | Zendy; Cao Neng | Zendy; Xu Wang | Zendy

Open Access

Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China

Author(s) -

Juan Ni,

Ling Zhang,

Tao Zhou,

Weijiang Xu,

Jinglun Xue,

Cao Neng,

Xu Wang

Publication year - 2017

Publication title -

journal of the chinese medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 42

eISSN - 1728-7731

pISSN - 1726-4901

DOI - 10.1016/j.jcma.2016.07.005

Subject(s) - methylenetetrahydrofolate reductase , vitamin b12 , homocysteine , medicine , genotype , endocrinology , hyperhomocysteinemia , biology , genetics , gene

An increased serum total homocysteine (tHcy) concentration is typically associated with genetic defects involved in Hcy metabolism or related nutritional deficiencies. In this study, the combined effects of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and folate and vitamin B12 deficiency on serum total Hcy (tHcy) levels were evaluated in a healthy Chinese population in Yunnan Province, China.

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