Open AccessShorter GT repeats in the heme oxygenase-1 gene promoter are associated with a lower severity score in coronary artery disease
Author(s) -
KaeWoei Liang,
Wayne H.-H. Sheu,
Wen-Lieng Lee,
ITe Lee,
Shih-Yi Lin,
ChihTai Ting,
WenJane Lee
Publication year - 2013
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2013.03.005
Subject(s) - allele , medicine , coronary artery disease , odds ratio , gastroenterology , allele frequency , gene , heme oxygenase , genetics , biology , heme , biochemistry , enzyme
The glutathione thymidine repeats [(GT)n] of the heme oxygenase (HO)-1 gene promoter have been shown to be correlated with the incidence of coronary artery disease (CAD), patients with shorter repeats being less likely to have CAD. In this study, we investigated whether (GT)n repeats in the HO-1 promoter were related to a quantitative angiographic severity of CAD.
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