Generalized depletion of free nerve endings and decrease of cutaneous nervous innervation in streptozotocin-induced painful and painless diabetic rats | Zendy

Chi-Chun Chu | Zendy; Shwun-De Wang | Zendy; Joseph S. Chiang | Zendy; Shung-Tai Ho | Zendy

Open Access

Generalized depletion of free nerve endings and decrease of cutaneous nervous innervation in streptozotocin-induced painful and painless diabetic rats

Author(s) -

Chi-Chun Chu,

Shwun-De Wang,

Joseph S. Chiang,

Shung-Tai Ho

Publication year - 2012

Publication title -

journal of the chinese medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 42

eISSN - 1728-7731

pISSN - 1726-4901

DOI - 10.1016/j.jcma.2012.05.005

Subject(s) - medicine , streptozotocin , nerve fiber , diabetes mellitus , free nerve ending , peripheral neuropathy , peripheral , diabetic neuropathy , pathological , peripheral nervous system , endocrinology , anatomy , central nervous system

The loss of peripheral nerve fiber is evident in chronic painful diabetic neuropathy. However, the correlation between peripheral fiber loss and the genesis of pain is unclear. Using the streptozotocin-induced diabetic rat model and focusing on free nerve endings, we attempted to investigate the peripheral changes that elicit pain syndromes in diabetes.

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