Significance of TRIM29 and β-catenin expression in non-small-cell lung cancer | Zendy

Zhiyi Zhou | Zendy; Guoyi Yang | Zendy; Jing Zhou | Zendy; Minhong Yu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Significance of TRIM29 and β-catenin expression in non-small-cell lung cancer

Author(s) -

Zhiyi Zhou,

Guoyi Yang,

Jing Zhou,

Minhong Yu

Publication year - 2012

Publication title -

journal of the chinese medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 42

eISSN - 1728-7731

pISSN - 1726-4901

DOI - 10.1016/j.jcma.2012.04.015

Subject(s) - immunohistochemistry , wnt signaling pathway , lung cancer , cancer research , adenocarcinoma , medicine , lymph node metastasis , metastasis , stage (stratigraphy) , pathological , biology , pathology , cancer , oncology , signal transduction , microbiology and biotechnology , paleontology

TRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported to be up-regulated or be down-regulated in many cancer types, suggesting the oncogenic function of TRIM29 may be depend on different molecular signaling pathway. It was found that β-catenin function (a key molecule in the Wnt signaling pathway) was required for TRIM29's oncogenic effects. TRIM29 gene expression was also found to be heterogeneous in non-small-cell lung cancer (NSCLC) subtypes. In this study, the possible associations of TRIM29 expression with clinicopathological factors, prognosis, and β-catenin in human NSCLC were analyzed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research