Open AccessInhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation
Author(s) -
Mia A. Shandell,
Alina L. Capatina,
Samantha M. Lawrence,
William J. Brackenbury,
Dimitris Lagos
Publication year - 2022
Publication title -
journal of biological chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.361
H-Index - 513
eISSN - 1067-8816
pISSN - 0021-9258
DOI - 10.1016/j.jbc.2022.101707
Subject(s) - gene knockdown , ouabain , cardiac glycoside , downregulation and upregulation , chemistry , immune checkpoint , kynurenine , cancer cell , cancer research , immune system , digoxin , microbiology and biotechnology , tryptophan , biochemistry , biology , medicine , cancer , immunotherapy , immunology , amino acid , apoptosis , organic chemistry , gene , sodium , heart failure
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