Open AccessLocal interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase
Author(s) -
I. Furey,
Shrenik Mehta,
Banumathi Sankaran,
Liya Hu,
B. V. Venkataram Prasad,
Timothy Palzkill
Publication year - 2021
Publication title -
journal of biological chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.361
H-Index - 513
eISSN - 1067-8816
pISSN - 0021-9258
DOI - 10.1016/j.jbc.2021.100799
Subject(s) - active site , key (lock) , loop (graph theory) , carbapenem , hydrolysis , chemistry , stereochemistry , combinatorial chemistry , biology , biochemistry , catalysis , mathematics , ecology , antibiotics , combinatorics
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