Nanomaterial-based surface-assisted laser desorption/ionization mass spectrometry of peptides and proteins | Zendy

Cheng-Kang Chiang | Zendy; M.F. Chiang | Zendy; ZongHong Lin | Zendy; Guo-Yu Lan | Zendy; YangWei Lin | Zendy; HuanTsung Chang | Zendy

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Nanomaterial-based surface-assisted laser desorption/ionization mass spectrometry of peptides and proteins

Author(s) -

Cheng-Kang Chiang,

M.F. Chiang,

ZongHong Lin,

Guo-Yu Lan,

YangWei Lin,

HuanTsung Chang

Publication year - 2010

Publication title -

journal of the american society for mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.961

H-Index - 127

eISSN - 1879-1123

pISSN - 1044-0305

DOI - 10.1016/j.jasms.2010.02.028

Subject(s) - chemistry , mass spectrometry , surface enhanced laser desorption/ionization , nanomaterials , protein mass spectrometry , desorption , proteomics , laser , matrix assisted laser desorption/ionization , chromatography , ionization , analytical chemistry (journal) , nanotechnology , tandem mass spectrometry , organic chemistry , biochemistry , adsorption , ion , materials science , physics , optics , gene

We have investigated six nanomaterials for their applicability as surfaces for the analyses of peptides and proteins using surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). Gold nanoparticles (NPs) were useful nanomaterials for small analytes (e.g., glutathione); Pt nanosponges and Fe(3)O(4) NPs were efficient nanomaterials for proteins, with an upper detectable mass limit of ca. 25 kDa. Nanomaterials have several advantages over organic matrices, including lower limits of detection for small analytes and lower batch-to-batch variations (fewer problems associated with "sweet spots"), when used in laser desorption/ionization mass spectrometry.

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