Spectroscopic evidence for mobilization of amide position protons during CID of model peptide ions | Zendy

Samuel Molesworth | Zendy; Christopher M. Leavitt | Zendy; Gary S. Groenewold | Zendy; Jos Oomens | Zendy; Jeffrey D. Steill | Zendy; Michael J. Van Stipdonk | Zendy

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Spectroscopic evidence for mobilization of amide position protons during CID of model peptide ions

Author(s) -

Samuel Molesworth,

Christopher M. Leavitt,

Gary S. Groenewold,

Jos Oomens,

Jeffrey D. Steill,

Michael J. Van Stipdonk

Publication year - 2009

Publication title -

journal of the american society for mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.961

H-Index - 127

eISSN - 1879-1123

pISSN - 1044-0305

DOI - 10.1016/j.jasms.2009.06.007

Subject(s) - infrared multiphoton dissociation , chemistry , oxazolone , protonation , fragmentation (computing) , amide , dissociation (chemistry) , photochemistry , pyridine , ion , spectroscopy , infrared spectroscopy , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , physics , quantum mechanics , computer science , operating system

Infrared multiple photon dissociation (IRMPD) spectroscopy was used to study formation of b2+ from nicotinyl-glycine-glycine-methyl ester (NicGGOMe). IRMPD shows that NicGGOMe is protonated at the pyridine ring of the nicotinyl group, and more importantly, that b2+ from NicGGOMe is not protonated at the oxazolone ring, as would be expected if the species were generated on the conventional bn+/yn+ oxazolone pathway, but at the pyridine ring instead. IRMPD data support a hypothesis that formation of b2+ from NicGGOMe involves mobilization and transfer of an amide position proton during the fragmentation reaction.

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