Open AccessConstruction of a versatile high precision ambient ionization source for direct analysis and imaging
Author(s) -
Jason S. Sampson,
Adam M. Hawkridge,
David C. Muddiman
Publication year - 2008
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/j.jasms.2008.06.013
Subject(s) - chemistry , ionization , desorption electrospray ionization , matrix assisted laser desorption electrospray ionization , ambient ionization , electrospray ionization , ion source , mass spectrometry , desorption , analytical chemistry (journal) , laser , chromatography , chemical ionization , electron ionization , ion , optics , physics , organic chemistry , adsorption
The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) are described in full detail, including a complete parts list. The computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis of peptides and proteins ranging from 1 to 17 kDa. The high stability ionization source platform described herein demonstrates both the advantages of the new MALDESI source and versatility for application to numerous desorption and ionization techniques.