Imaging of aβ-peptide distribution in whole-body mice sections by MALDI mass spectrometry | Zendy

Markus Stoeckli | Zendy; Dieter Staab | Zendy; Alain Schweitzer | Zendy; James Gardiner | Zendy; Dieter Seebàch | Zendy

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Imaging of aβ-peptide distribution in whole-body mice sections by MALDI mass spectrometry

Author(s) -

Markus Stoeckli,

Dieter Staab,

Alain Schweitzer,

James Gardiner,

Dieter Seebàch

Publication year - 2007

Publication title -

journal of the american society for mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.961

H-Index - 127

eISSN - 1879-1123

pISSN - 1044-0305

DOI - 10.1016/j.jasms.2007.08.005

Subject(s) - chemistry , peptide , mass spectrometry , chromatography , mass spectrometry imaging , biochemistry

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

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