Open AccessImaging of aβ-peptide distribution in whole-body mice sections by MALDI mass spectrometry
Author(s) -
Markus Stoeckli,
Dieter Staab,
A. Schweitzer,
James Gardiner,
Dieter Seebàch
Publication year - 2007
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/j.jasms.2007.08.005
Subject(s) - chemistry , peptide , mass spectrometry , chromatography , mass spectrometry imaging , biochemistry
Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.