Open AccessInvestigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler
Author(s) -
J. Will Thompson,
John W. Eschelbach,
Richard T. Wilburn,
James W. Jorgenson
Publication year - 2005
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/j.jasms.2004.11.012
Subject(s) - chemistry , quadrupole mass analyzer , mass spectrometry , analytical chemistry (journal) , electrospray , quadrupole , electrospray ionization , ionization , ion current , ion , spectrometer , triple quadrupole mass spectrometer , atomic physics , chromatography , optics , tandem mass spectrometry , selected reaction monitoring , physics , organic chemistry
A novel instrument for profiling the current density of nanoelectrospray ionization plumes in three dimensions has been developed. A hemispherically-shaped electrostatic lens at atmospheric pressure is found to be able to compress the space-charge in nano-ESI and increase the average current density in the plume to three times the nominal value. Ion transmission into a single-quadrupole mass spectrometer is found to roughly double using the electrostatic lens. Data also suggest that ion transmission into the first vacuum region for a skimmer-type mass spectrometer interface using nano-ESI may be typically 40% or better with no special focusing device used.