Fragmentation of protonated ions of peptides containing cysteine, cysteine sulfinic acid, and cysteine sulfonic acid | Zendy

Yinsheng Wang | Zendy; Vivekananda Shetty | Zendy; Lijie Men | Zendy; Qibin Zhang | Zendy

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Fragmentation of protonated ions of peptides containing cysteine, cysteine sulfinic acid, and cysteine sulfonic acid

Author(s) -

Yinsheng Wang,

Vivekananda Shetty,

Lijie Men,

Qibin Zhang

Publication year - 2004

Publication title -

journal of the american society for mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.961

H-Index - 127

eISSN - 1879-1123

pISSN - 1044-0305

DOI - 10.1016/j.jasms.2004.01.005

Subject(s) - chemistry , cysteine , protonation , fragmentation (computing) , sulfinic acid , sulfonic acid , cysteic acid , ion , biochemistry , cystine , organic chemistry , enzyme , computer science , operating system

The oxidation of the sulfhydryl group in cysteine to sulfenic acid, sulfinic acid, and sulfonic acid in proteins is important in a number of enzymatic processes. In this study we examined the fragmentation of four peptides containing cysteine, cysteine sulfinic acid (Cys-SO(2)H), and cysteine sulfonic acid (Cys-SO(3)H) in an ion-trap mass spectrometer. Our results show that the presence of a Cys-SO(2)H in a peptide leads to preferential cleavage of the amide bond at the C-terminal side of the oxidized cysteine residue. The results are important for the determination of the site of the cysteine oxidation and might be useful for the sequencing of cysteine-containing peptides.

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