Open AccessAttachment of metal trications to peptides
Author(s) -
Alexandre A. Shvartsburg,
Richard C. Jones
Publication year - 2004
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/j.jasms.2003.11.005
Subject(s) - chemistry , electrospray ionization , protonation , adduct , metal , electrospray , mass spectrometry , bradykinin , metal ions in aqueous solution , peptide , oxidation state , ion , combinatorial chemistry , stereochemistry , crystallography , inorganic chemistry , organic chemistry , chromatography , biochemistry , receptor
Gas-phase complexes of triply charged metal ions with peptides may be readily produced using electrospray ionization, including for small peptides such as bradykinin and peptides with no basic residues such as insulin chain A. Attachment without charge-reduction is demonstrated for all trications studied: La(3+), Al(3+), Ga(3+), Fe(3+), V(3+), and Cr(3+). The intensities of adducts are often comparable to, or even exceed, those of protonated analogs in any charge state.