Miniaturization of Mass Spectrometry Analysis Systems | Zendy

Wei Xu | Zendy; Nicholas E. Manicke | Zendy; R. Graham Cooks | Zendy; Zheng Ouyang | Zendy

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Miniaturization of Mass Spectrometry Analysis Systems

Author(s) -

Wei Xu,

Nicholas E. Manicke,

R. Graham Cooks,

Zheng Ouyang

Publication year - 2010

Publication title -

jala journal of the association for laboratory automation

Language(s) - English

Resource type - Journals

eISSN - 1540-2452

pISSN - 1535-5535

DOI - 10.1016/j.jala.2010.06.004

Subject(s) - miniaturization , mass spectrometry , desorption electrospray ionization , analytical chemistry (journal) , ambient ionization , ion trap , chemistry , ionization , direct electron ionization liquid chromatography–mass spectrometry interface , spectrometer , ion source , chemical ionization , materials science , ion , nanotechnology , chromatography , physics , optics , organic chemistry

The key concepts and technologies developed in our laboratories in Purdue University for the miniaturization of mass spectrometry analysis systems are introduced. Mass analyzers of simple geometries with a novel atmospheric pressure interface were used to allow reduction in the size of the ion trap mass spectrometer. Ambient ionization methods were developed and coupled to miniature mass spectrometers to allow direct MS analysis of complex samples without sample preparation and chemical separation. The performance of desorption electrospray ionization, low temperature plasma probe, paper spray, and two handheld MS systems, Mini 10 and Mini 11, are described with demonstrations of capabilities for chemical analysis.

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