Open AccessPopulation pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia
Author(s) -
Nadia Ben Fredj,
Haifa Ben Romdhane,
JeanBaptiste Woillard,
M. Chickaid,
Najeh Ben Fadhel,
Zohra Chadly,
Amel Chaabane,
Naceur A. Boughattas,
Karim Aouam
Publication year - 2021
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2021.01.033
Subject(s) - isoniazid , pharmacokinetics , medicine , dosing , volume of distribution , population , tuberculosis , pharmacology , pathology , environmental health
To develop a pharmacokinetic model of isoniazid (INH) concentration taking into account demographic factors and genetic variables [N-acetyltransferase 2 (NAT2) genotype], and to propose an initial INH dosage that could maximize the probability of achieving the desired INH concentration.
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