Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome | Zendy

Lawrence B. Afrin | Zendy; Leonard B. Weinstock | Zendy; Gerhard J. Molderings | Zendy

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Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

Author(s) -

Lawrence B. Afrin,

Leonard B. Weinstock,

Gerhard J. Molderings

Publication year - 2020

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2020.09.016

Subject(s) - covid-19 , mast cell , medicine , immunology , pandemic , virology , pathology , infectious disease (medical specialty) , disease , outbreak

One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2. Although only recently recognized, MC activation syndrome (MCAS), usually due to acquired MC clonality, is a chronic multisystem disorder with inflammatory and allergic themes, and an estimated prevalence of 17%. This paper describes a novel conjecture explaining how MCAS might cause a propensity for severe acute Covid-19 infection and chronic post-Covid-19 illnesses.

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